Tissue kallikrein permits early renal adaptation to potassium load

Early increases in renal kallikrein secretion on administration of potassium or ATP-sensitive potassium channel blockers in rats.

1 This study aimed to examine whether administration of potassium or ATP-sensitive potassium channel (KATP channel) blockers caused early increases in renal kallikrein (KK) secretion. To clarify this mechanism, the effect on renal KK secretion of a KATP channel blocker was compared with the effect resulting from use of an osmotic diuretic or volume load. Furthermore, the effect on potassium-ind...

Adaptation of Horsesickness Virus to Tissue Culture

Rapid renal potassium adaptation in rats.

The possibility that renal K adaptation, defined as the increased capacity to excrete an intravenous K load, can occur within hours of intake of a normal K ration was examined in fed and fasted rats. Rats maintained on a 12-h light-dark cycle were fed either a standard diet (fed rats) or had food removed before the onset of the dark phase to prevent the early dark phase ingestion (fasted rats)....

Renal adaptation to potassium in the adrenalectomized rabbit. Role of distal tubular sodium-potassium adenosine triphosphatase.

Potassium secretion and sodium-potassium adenosine triphosphatase (Na-K-ATPase) activity in the distal nephron segments are known to be influenced by the dietary intake of K+. This has been attributed to a change in the plasma aldosterone level, which also influences K+ secretion and Na-K-ATPase activity in the distal nephron. To investigate whether or not dietary K+ can modulate Na-K-ATPase ac...

Potassium supplement upregulates the expression of renal kallikrein and bradykinin B2 receptor in SHR.

High potassium intake is known to attenuate hypertension, glomerular lesion, ischemic damage, and stroke-associated death. Our recent studies showed that expression of recombinant kallikrein by somatic gene delivery reduced high blood pressure, cardiac hypertrophy, and renal injury in hypertensive animal models. The aim of this study is to explore the potential role of the tissue kallikrein-kin...